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Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson's disease

The co-enzyme nicotinamide adenine dinucleotide (NAD(+)) is an essential co-factor for cellular energy generation in mitochondria as well as for DNA repair mechanisms in the cell nucleus involving NAD(+)-consuming poly (ADP-ribose) polymerases (PARPs). Mitochondrial function is compromised in animal...

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Detalles Bibliográficos
Autores principales:	Lehmann, S, Costa, A C, Celardo, I, Loh, S H Y, Martins, L M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823968/ https://www.ncbi.nlm.nih.gov/pubmed/27031963 http://dx.doi.org/10.1038/cddis.2016.72

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