Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model

Background: Seven isoforms of histone deacetylase Class III have been reported - Sirtuin (SIRT) 1-7. We recently demonstrated that EX-527, an inhibitor of SIRT1, reduces mortality in a mouse model of lethal-cecal-ligation-and-puncture (CLP)-induced septic shock. Our present study was aimed at determ...

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Detalles Bibliográficos
Autores principales: Zhao, T., Alam, H.B., Liu, B., Bronson, R.T., Nikolian, V.C., Wu, E., Chong, W., Li, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824319/
https://www.ncbi.nlm.nih.gov/pubmed/26299770
http://dx.doi.org/10.2174/156652401507150903185852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824319/
https://www.ncbi.nlm.nih.gov/pubmed/26299770
http://dx.doi.org/10.2174/156652401507150903185852

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