Dynorphin 1-17 and Its N-Terminal Biotransformation Fragments Modulate Lipopolysaccharide-Stimulated Nuclear Factor-kappa B Nuclear Translocation, Interleukin-1beta and Tumor Necrosis Factor-alpha in Differentiated THP-1 Cells

Dynorphin 1–17, (DYN 1–17) opioid peptide produces antinociception following binding to the kappa-opioid peptide (KOP) receptor. Upon synthesis and release in inflamed tissues by immune cells, DYN 1–17 undergoes rapid biotransformation and yields a unique set of opioid and non-opioid fragments. Some...

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Detalles Bibliográficos
Autores principales: Fazalul Rahiman, Siti Sarah, Morgan, Michael, Gray, Paul, Shaw, Paul Nicholas, Cabot, Peter John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824444/
https://www.ncbi.nlm.nih.gov/pubmed/27055013
http://dx.doi.org/10.1371/journal.pone.0153005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824444/
https://www.ncbi.nlm.nih.gov/pubmed/27055013
http://dx.doi.org/10.1371/journal.pone.0153005

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