Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

Small cell lung cancer (SCLC) is an aggressive malignancy with limited treatment options. We previously found that PARP is overexpressed in SCLC and that targeting PARP reduces cell line and tumor growth in preclinical models. However, SCLC cell lines with PI3K/mTOR pathway activation were relativel...

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Detalles Bibliográficos
Autores principales: Cardnell, Robert J., Feng, Ying, Mukherjee, Seema, Diao, Lixia, Tong, Pan, Stewart, C. Allison, Masrorpour, Fatemeh, Fan, YouHong, Nilsson, Monique, Shen, Yuqiao, Heymach, John V., Wang, Jing, Byers, Lauren A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824499/
https://www.ncbi.nlm.nih.gov/pubmed/27055253
http://dx.doi.org/10.1371/journal.pone.0152584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824499/
https://www.ncbi.nlm.nih.gov/pubmed/27055253
http://dx.doi.org/10.1371/journal.pone.0152584

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