CD19xCD3 DART protein mediates human B-cell depletion in vivo in humanized BLT mice

Novel therapeutic strategies are needed for the treatment of hematologic malignancies; and bispecific antibody-derived molecules, such as dual-affinity re-targeting (DART) proteins, are being developed to redirect T cells to kill target cells expressing tumor or viral antigens. Here we present our f...

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Detalles Bibliográficos
Autores principales: Tsai, Perry, Thayer, William O, Liu, Liqin, Silvestri, Guido, Nordstrom, Jeffrey L, Garcia, J Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824566/
https://www.ncbi.nlm.nih.gov/pubmed/27119115
http://dx.doi.org/10.1038/mto.2015.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824566/
https://www.ncbi.nlm.nih.gov/pubmed/27119115
http://dx.doi.org/10.1038/mto.2015.24

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