Alkaline Phosphatase and Hypophosphatasia

Hypophosphatasia (HPP) results from ALPL mutations leading to deficient activity of the tissue-non-specific alkaline phosphatase isozyme (TNAP) and thereby extracellular accumulation of inorganic pyrophosphate (PP(i)), a natural substrate of TNAP and potent inhibitor of mineralization. Thus, HPP fea...

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Detalles Bibliográficos
Autores principales: Millán, José Luis, Whyte, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824800/
https://www.ncbi.nlm.nih.gov/pubmed/26590809
http://dx.doi.org/10.1007/s00223-015-0079-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824800/
https://www.ncbi.nlm.nih.gov/pubmed/26590809
http://dx.doi.org/10.1007/s00223-015-0079-1

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