MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans

The Caenorhabditis elegans DEG/ENaC proteins MEC-4 and MEC-10 transduce gentle touch in the six touch receptor neurons . Gain-of-function mutations of mec-4 and mec-4(d) result in a hyperactive channel and neurodegeneration in vivo. Loss of MEC-6, a putative DEG/ENaC-specific chaperone, and of the s...

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Detalles Bibliográficos
Autores principales: Chen, Yushu, Bharill, Shashank, O’Hagan, Robert, Isacoff, Ehud Y., Chalfie, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2016
Materias:
Mutant Screen Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825646/
https://www.ncbi.nlm.nih.gov/pubmed/27172609
http://dx.doi.org/10.1534/g3.115.023507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825646/
https://www.ncbi.nlm.nih.gov/pubmed/27172609
http://dx.doi.org/10.1534/g3.115.023507

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