Cargando…

MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans

The Caenorhabditis elegans DEG/ENaC proteins MEC-4 and MEC-10 transduce gentle touch in the six touch receptor neurons . Gain-of-function mutations of mec-4 and mec-4(d) result in a hyperactive channel and neurodegeneration in vivo. Loss of MEC-6, a putative DEG/ENaC-specific chaperone, and of the s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yushu, Bharill, Shashank, O’Hagan, Robert, Isacoff, Ehud Y., Chalfie, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2016
Materias:	Mutant Screen Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825646/ https://www.ncbi.nlm.nih.gov/pubmed/27172609 http://dx.doi.org/10.1534/g3.115.023507

Ejemplares similares

Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins
por: Chen, Yushu, et al.
Publicado: (2016)

Effect of the protease plasmin on C. elegans hyperactive DEG/ENaC channels MEC-4(d) and UNC-8(d)
por: Johnson, Christina K., et al.
Publicado: (2021)

Corrigendum: Effect of the protease plasmin on C. elegans hyperactive DEG/ENaC channels MEC-4(d) and UNC-8(d)
Publicado: (2021)

Gain-of-Function Mutations in the MEC-4 DEG/ENaC Sensory Mechanotransduction Channel Alter Gating and Drug Blockade
por: Brown, Austin L., et al.
Publicado: (2007)

MEC-2 and MEC-6 in the Caenorhabditis elegans Sensory Mechanotransduction Complex: Auxiliary Subunits that Enable Channel Activity
por: Brown, Austin L., et al.
Publicado: (2008)

Identification of Nonviable Genes Affecting Touch Sensitivity in Caenorhabditis elegans Using Neuronally Enhanced Feeding RNA Interference
por: Chen, Xiaoyin, et al.
Publicado: (2015)

Conditional Gene Expression and RNAi Using MEC-8-Dependent Splicing in C. elegans
por: Calixto, Andrea, et al.
Publicado: (2010)

MRSA Harboring mecA Variant Gene mecC, France
por: Laurent, Frederic, et al.
Publicado: (2012)

Impact of the Stringent Stress Response on the Expression of Methicillin Resistance in Staphylococcaceae Strains Carrying mecA, mecA1 and mecC
por: Milheiriço, Catarina, et al.
Publicado: (2022)

Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in Caenorhabditis elegans
Publicado: (1996)

Identification of Suppressors of top-2 Embryonic Lethality in Caenorhabditis elegans
por: Bhandari, Nirajan, et al.
Publicado: (2020)

A Forward Genetic Screen for Suppressors of Somatic P Granules in Caenorhabditis elegans
por: Kelly, Ashley L., et al.
Publicado: (2015)

A Network of Chromatin Factors Is Regulating the Transition to Postembryonic Development in Caenorhabditis elegans
por: Erdelyi, Peter, et al.
Publicado: (2016)

Novel exc Genes Involved in Formation of the Tubular Excretory Canals of Caenorhabditis elegans
por: Al-Hashimi, Hikmat, et al.
Publicado: (2019)

Forward Genetic Screen for Caenorhabditis elegans Mutants with a Shortened Locomotor Healthspan
por: Kawamura, Kazuto, et al.
Publicado: (2019)

Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep
por: Huang, Huiyan, et al.
Publicado: (2017)

A genetic screen for temperature-sensitive morphogenesis-defective Caenorhabditis elegans mutants
por: Jud, Molly C, et al.
Publicado: (2021)

Staphylococcal cassette chromosome mec containing a novel mec gene complex, B4
por: Sabat, Artur J, et al.
Publicado: (2021)

RNAi Screen Identifies Novel Regulators of RNP Granules in the Caenorhabditis elegans Germ Line
por: Wood, Megan P., et al.
Publicado: (2016)

A sensitized genetic screen to identify regulators of Caenorhabditis elegans germline stem cells
por: Robinson-Thiewes, Sarah, et al.
Publicado: (2021)

A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans
por: Neal, Scott J., et al.
Publicado: (2016)

ENaC/DEG in Tumor Development and Progression
por: Liu, Cui, et al.
Publicado: (2016)

First mecC and mecA Positive Livestock-Associated Methicillin Resistant Staphylococcus aureus (mecC MRSA/LA-MRSA) from Dairy Cattle in Malaysia
por: Aklilu, Erkihun, et al.
Publicado: (2020)

Complete Circular Genome Sequence of a mecB- and mecD-Containing Strain of Macrococcus canis
por: Schwendener, Sybille, et al.
Publicado: (2021)

MEC/Cloud Orchestrator to Facilitate Private/Local Beyond 5G with MEC and Proof-of-Concept Implementation
por: Nakazato, Jin, et al.
Publicado: (2022)

Uncovering Buffered Pleiotropy: A Genome-Scale Screen for mel-28 Genetic Interactors in Caenorhabditis elegans
por: Fernandez, Anita G., et al.
Publicado: (2013)

Genome-wide RNAi screen for regulators of UPR(mt) in Caenorhabditis elegans mutants with defects in mitochondrial fusion
por: Haeussler, Simon, et al.
Publicado: (2021)

Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing
por: Jaramillo-Lambert, Aimee, et al.
Publicado: (2015)

MEC-17 is an α-tubulin acetyltransferase
por: Akella, Jyothi S., et al.
Publicado: (2010)

Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC
por: Harrison, Ewan M, et al.
Publicado: (2013)

Hierarchical MEC Servers Deployment and User-MEC Server Association in C-RANs over WDM Ring Networks
por: Liu, Zhen, et al.
Publicado: (2020)

Prevalence of mecA- and mecC-Associated Methicillin-Resistant Staphylococcus aureus in Clinical Specimens, Punjab, Pakistan
por: Idrees, Muhammad Mubashar, et al.
Publicado: (2023)

A Caenorhabditis elegans Zinc Finger Transcription Factor, ztf-6, Required for the Specification of a Dopamine Neuron-Producing Lineage
por: Doitsidou, Maria, et al.
Publicado: (2018)

Combining Auxin-Induced Degradation and RNAi Screening Identifies Novel Genes Involved in Lipid Bilayer Stress Sensing in Caenorhabditis elegans
por: Venz, Richard, et al.
Publicado: (2020)

A Screen of the Conserved Kinome for Negative Regulators of LIN-12 Negative Regulatory Region (“NRR”)-Missense Activity in Caenorhabditis elegans
por: Deng, Yuting, et al.
Publicado: (2019)

Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors
por: Chatzigeorgiou, Marios, et al.
Publicado: (2010)

Deficient mechanosensation in mec-3 decreases precipice response in C. elegans
por: Mitchell, Robin M, et al.
Publicado: (2021)

A Strategy To Isolate Modifiers of Caenorhabditis elegans Lethal Mutations: Investigating the Endoderm Specifying Ability of the Intestinal Differentiation GATA Factor ELT-2
por: Wiesenfahrt, Tobias, et al.
Publicado: (2018)

A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused by Elevated GLP-1/Notch Signaling in Caenorhabditis elegans
por: Dalfó, Diana, et al.
Publicado: (2020)

par-1, Atypical pkc, and PP2A/B55 sur-6 Are Implicated in the Regulation of Exocyst-Mediated Membrane Trafficking in Caenorhabditis elegans
por: Jiu, Yaming, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_k62uhbkfvpkt494apna24ogsud