ATPase-Dependent Quality Control of DNA Replication Origin Licensing

The regulated loading of the Mcm2-7 DNA helicase into pre-replicative complexes (pre-RCs) at multiple replication origins ensures precise once per cell cycle replication in eukaryotic cells. Origin Recognition Complex (ORC), Cdc6 and Cdt1 load Mcm2-7 into a double hexamer bound around duplex DNA in...

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Detalles Bibliográficos
Autores principales: Frigola, Jordi, Remus, Dirk, Mehanna, Amina, Diffley, John F. X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825857/
https://www.ncbi.nlm.nih.gov/pubmed/23474987
http://dx.doi.org/10.1038/nature11920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825857/
https://www.ncbi.nlm.nih.gov/pubmed/23474987
http://dx.doi.org/10.1038/nature11920

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