Histone Deacetylase Inhibitors Trichostatin A and MCP30 Relieve Benzene-Induced Hematotoxicity via Restoring Topoisomerase IIα

Dysfunction of histone acetylation inhibits topoisomerase IIα (Topo IIα), which is implicated in benzene-induced hematotoxicity in patients with chronic benzene exposure. Whether histone deacetylase (HDAC) inhibitors can relieve benzene-induced hematotoxicity remains unclear. Here we showed that hyd...

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Detalles Bibliográficos
Autores principales: Chen, Jingjing, Zheng, Zhouyi, Chen, Yi, Li, Jiaqi, Qian, Shanhu, Shi, Yifen, Sun, Lan, Han, Yixiang, Zhang, Shenghui, Yu, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826000/
https://www.ncbi.nlm.nih.gov/pubmed/27058040
http://dx.doi.org/10.1371/journal.pone.0153330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826000/
https://www.ncbi.nlm.nih.gov/pubmed/27058040
http://dx.doi.org/10.1371/journal.pone.0153330

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