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Single calcium channel domain gating of synaptic vesicle fusion at fast synapses; analysis by graphic modeling
At fast-transmitting presynaptic terminals Ca(2+) enter through voltage gated calcium channels (CaVs) and bind to a synaptic vesicle (SV) -associated calcium sensor (SV-sensor) to gate fusion and discharge. An open CaV generates a high-concentration plume, or nanodomain of Ca(2+) that dissipates pre...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826128/ https://www.ncbi.nlm.nih.gov/pubmed/26457441 http://dx.doi.org/10.1080/19336950.2015.1098793 |