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A chemical screen to identify inducers of the mitochondrial unfolded protein response in C. elegans

We previously showed that inhibition of the mevalonate pathway in C. elegans causes inhibition of protein prenylation, developmental arrest and lethality. We also showed that constitutive activation of the mitochondrial unfolded protein response, UPR(mt), is an effective way for C. elegans to become...

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Detalles Bibliográficos
Autores principales: Rauthan, Manish, Pilon, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826155/
https://www.ncbi.nlm.nih.gov/pubmed/27123370
http://dx.doi.org/10.1080/21624054.2015.1096490