Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells

Smac mimetics antagonize IAP proteins, which are highly expressed in several cancers. Recent reports indicate that Smac mimetics trigger a broad cytokine response and synergize with immune modulators to induce cell death. Here, we identify a differential requirement of TRAIL or TNFα as mediators of...

Descripción completa

Detalles Bibliográficos
Autores principales: Roesler, Stefanie, Eckhardt, Ines, Wolf, Sebastian, Fulda, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research paper: Autophagy and Cell Death
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826164/
https://www.ncbi.nlm.nih.gov/pubmed/26788912
http://dx.doi.org/10.18632/oncotarget.6915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826164/
https://www.ncbi.nlm.nih.gov/pubmed/26788912
http://dx.doi.org/10.18632/oncotarget.6915

Ejemplares similares