Sphingosine kinase 1 is required for TGF-β mediated fibroblast-to-myofibroblast differentiation in ovarian cancer

Sphingosine kinase 1 (SPHK1), the enzyme that produces sphingosine 1 phosphate (S1P), is known to be highly expressed in many cancers. However, the role of SPHK1 in cells of the tumor stroma remains unclear. Here, we show that SPHK1 is highly expressed in the tumor stroma of high-grade serous ovaria...

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Detalles Bibliográficos
Autores principales: Beach, Jessica A., Aspuria, Paul-Joseph P., Cheon, Dong-Joo, Lawrenson, Kate, Agadjanian, Hasmik, Walsh, Christine S., Karlan, Beth Y., Orsulic, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826197/
https://www.ncbi.nlm.nih.gov/pubmed/26716409
http://dx.doi.org/10.18632/oncotarget.6703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826197/
https://www.ncbi.nlm.nih.gov/pubmed/26716409
http://dx.doi.org/10.18632/oncotarget.6703

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