Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity

Precision oncology trials based on tumor gene sequencing depend on robust knowledge about the phenotypic consequences of the genetic variants identified in patients' tumors. Mutations in AKT1-3 occur in 3-5% of human cancers. Although a single hotspot mutation, E17K, is the most common, well ch...

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Detalles Bibliográficos
Autores principales: Yi, Kyung H., Lauring, Josh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826202/
https://www.ncbi.nlm.nih.gov/pubmed/26701849
http://dx.doi.org/10.18632/oncotarget.6648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826202/
https://www.ncbi.nlm.nih.gov/pubmed/26701849
http://dx.doi.org/10.18632/oncotarget.6648

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