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Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity
Precision oncology trials based on tumor gene sequencing depend on robust knowledge about the phenotypic consequences of the genetic variants identified in patients' tumors. Mutations in AKT1-3 occur in 3-5% of human cancers. Although a single hotspot mutation, E17K, is the most common, well ch...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals LLC
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826202/ https://www.ncbi.nlm.nih.gov/pubmed/26701849 http://dx.doi.org/10.18632/oncotarget.6648 |