The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1

The B56γ-containing protein phosphatase 2A (PP2A-B56γ) has been postulated to have tumor suppressive functions. Here, we report regulation of p27KIP1 subcellular localization by PP2A-B56γ3. B56γ3 overexpression enhanced nuclear localization of p27KIP1, whereas knockdown of B56γ3 decreased p27KIP1 nu...

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Detalles Bibliográficos
Autores principales: Lai, Tai-Yu, Yen, Chia-Jui, Tsai, Hung-Wen, Yang, Yu-San, Hong, Wei-Fu, Chiang, Chi-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826225/
https://www.ncbi.nlm.nih.gov/pubmed/26684356
http://dx.doi.org/10.18632/oncotarget.6609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826225/
https://www.ncbi.nlm.nih.gov/pubmed/26684356
http://dx.doi.org/10.18632/oncotarget.6609

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