Association of cancer mortality with postdiagnosis overweight and obesity using body mass index

Although overweight and obesity increase cancer risk, it is still controversial with respect to cancer mortality. In the current study, we enrolled 2670 patients of 14 tumor types from the Cancer Genome Atlas (TCGA) project, to identify the prognostic role of overweight and obesity in cancer patient...

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Autores principales: Xu, Xinsen, Zhou, Lei, Miao, Runchen, Chen, Wei, Zhou, Yanyan, Pang, Qing, Qu, Kai, Liu, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826262/
https://www.ncbi.nlm.nih.gov/pubmed/26657291
http://dx.doi.org/10.18632/oncotarget.6517
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author Xu, Xinsen
Zhou, Lei
Miao, Runchen
Chen, Wei
Zhou, Yanyan
Pang, Qing
Qu, Kai
Liu, Chang
author_facet Xu, Xinsen
Zhou, Lei
Miao, Runchen
Chen, Wei
Zhou, Yanyan
Pang, Qing
Qu, Kai
Liu, Chang
author_sort Xu, Xinsen
collection PubMed
description Although overweight and obesity increase cancer risk, it is still controversial with respect to cancer mortality. In the current study, we enrolled 2670 patients of 14 tumor types from the Cancer Genome Atlas (TCGA) project, to identify the prognostic role of overweight and obesity in cancer patients. After dividing the patients into different groups by the body mass index (BMI), we found significant lower mortality in the obesity group. In addition, we also treat BMI value as a binary categorical variable or continuous variable, respectively. We found significant lower mortality in the higher BMI group. Furthermore, when focusing on each tumor type, cervical cancer and bladder cancer showed lower mortality in the patients with higher BMI values. Taken together, our results demonstrate that postdiagnosis obesity might indicate a better prognosis in cancer patients. However, these findings should be interpreted cautiously because of small sample size.
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spelling pubmed-48262622016-05-09 Association of cancer mortality with postdiagnosis overweight and obesity using body mass index Xu, Xinsen Zhou, Lei Miao, Runchen Chen, Wei Zhou, Yanyan Pang, Qing Qu, Kai Liu, Chang Oncotarget Research Paper Although overweight and obesity increase cancer risk, it is still controversial with respect to cancer mortality. In the current study, we enrolled 2670 patients of 14 tumor types from the Cancer Genome Atlas (TCGA) project, to identify the prognostic role of overweight and obesity in cancer patients. After dividing the patients into different groups by the body mass index (BMI), we found significant lower mortality in the obesity group. In addition, we also treat BMI value as a binary categorical variable or continuous variable, respectively. We found significant lower mortality in the higher BMI group. Furthermore, when focusing on each tumor type, cervical cancer and bladder cancer showed lower mortality in the patients with higher BMI values. Taken together, our results demonstrate that postdiagnosis obesity might indicate a better prognosis in cancer patients. However, these findings should be interpreted cautiously because of small sample size. Impact Journals LLC 2015-12-09 /pmc/articles/PMC4826262/ /pubmed/26657291 http://dx.doi.org/10.18632/oncotarget.6517 Text en Copyright: © 2016 Xu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Xu, Xinsen
Zhou, Lei
Miao, Runchen
Chen, Wei
Zhou, Yanyan
Pang, Qing
Qu, Kai
Liu, Chang
Association of cancer mortality with postdiagnosis overweight and obesity using body mass index
title Association of cancer mortality with postdiagnosis overweight and obesity using body mass index
title_full Association of cancer mortality with postdiagnosis overweight and obesity using body mass index
title_fullStr Association of cancer mortality with postdiagnosis overweight and obesity using body mass index
title_full_unstemmed Association of cancer mortality with postdiagnosis overweight and obesity using body mass index
title_short Association of cancer mortality with postdiagnosis overweight and obesity using body mass index
title_sort association of cancer mortality with postdiagnosis overweight and obesity using body mass index
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826262/
https://www.ncbi.nlm.nih.gov/pubmed/26657291
http://dx.doi.org/10.18632/oncotarget.6517
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