Association of cancer mortality with postdiagnosis overweight and obesity using body mass index
Although overweight and obesity increase cancer risk, it is still controversial with respect to cancer mortality. In the current study, we enrolled 2670 patients of 14 tumor types from the Cancer Genome Atlas (TCGA) project, to identify the prognostic role of overweight and obesity in cancer patient...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826262/ https://www.ncbi.nlm.nih.gov/pubmed/26657291 http://dx.doi.org/10.18632/oncotarget.6517 |
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author | Xu, Xinsen Zhou, Lei Miao, Runchen Chen, Wei Zhou, Yanyan Pang, Qing Qu, Kai Liu, Chang |
author_facet | Xu, Xinsen Zhou, Lei Miao, Runchen Chen, Wei Zhou, Yanyan Pang, Qing Qu, Kai Liu, Chang |
author_sort | Xu, Xinsen |
collection | PubMed |
description | Although overweight and obesity increase cancer risk, it is still controversial with respect to cancer mortality. In the current study, we enrolled 2670 patients of 14 tumor types from the Cancer Genome Atlas (TCGA) project, to identify the prognostic role of overweight and obesity in cancer patients. After dividing the patients into different groups by the body mass index (BMI), we found significant lower mortality in the obesity group. In addition, we also treat BMI value as a binary categorical variable or continuous variable, respectively. We found significant lower mortality in the higher BMI group. Furthermore, when focusing on each tumor type, cervical cancer and bladder cancer showed lower mortality in the patients with higher BMI values. Taken together, our results demonstrate that postdiagnosis obesity might indicate a better prognosis in cancer patients. However, these findings should be interpreted cautiously because of small sample size. |
format | Online Article Text |
id | pubmed-4826262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-48262622016-05-09 Association of cancer mortality with postdiagnosis overweight and obesity using body mass index Xu, Xinsen Zhou, Lei Miao, Runchen Chen, Wei Zhou, Yanyan Pang, Qing Qu, Kai Liu, Chang Oncotarget Research Paper Although overweight and obesity increase cancer risk, it is still controversial with respect to cancer mortality. In the current study, we enrolled 2670 patients of 14 tumor types from the Cancer Genome Atlas (TCGA) project, to identify the prognostic role of overweight and obesity in cancer patients. After dividing the patients into different groups by the body mass index (BMI), we found significant lower mortality in the obesity group. In addition, we also treat BMI value as a binary categorical variable or continuous variable, respectively. We found significant lower mortality in the higher BMI group. Furthermore, when focusing on each tumor type, cervical cancer and bladder cancer showed lower mortality in the patients with higher BMI values. Taken together, our results demonstrate that postdiagnosis obesity might indicate a better prognosis in cancer patients. However, these findings should be interpreted cautiously because of small sample size. Impact Journals LLC 2015-12-09 /pmc/articles/PMC4826262/ /pubmed/26657291 http://dx.doi.org/10.18632/oncotarget.6517 Text en Copyright: © 2016 Xu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Xu, Xinsen Zhou, Lei Miao, Runchen Chen, Wei Zhou, Yanyan Pang, Qing Qu, Kai Liu, Chang Association of cancer mortality with postdiagnosis overweight and obesity using body mass index |
title | Association of cancer mortality with postdiagnosis overweight and obesity using body mass index |
title_full | Association of cancer mortality with postdiagnosis overweight and obesity using body mass index |
title_fullStr | Association of cancer mortality with postdiagnosis overweight and obesity using body mass index |
title_full_unstemmed | Association of cancer mortality with postdiagnosis overweight and obesity using body mass index |
title_short | Association of cancer mortality with postdiagnosis overweight and obesity using body mass index |
title_sort | association of cancer mortality with postdiagnosis overweight and obesity using body mass index |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826262/ https://www.ncbi.nlm.nih.gov/pubmed/26657291 http://dx.doi.org/10.18632/oncotarget.6517 |
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