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Human Knockout Carriers: Dead, Diseased, Healthy, or Improved?

Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function t...

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Detalles Bibliográficos
Autores principales: Narasimhan, Vagheesh M., Xue, Yali, Tyler-Smith, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826344/
https://www.ncbi.nlm.nih.gov/pubmed/26988438
http://dx.doi.org/10.1016/j.molmed.2016.02.006