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Human Knockout Carriers: Dead, Diseased, Healthy, or Improved?
Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function t...
Autores principales: | Narasimhan, Vagheesh M., Xue, Yali, Tyler-Smith, Chris |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826344/ https://www.ncbi.nlm.nih.gov/pubmed/26988438 http://dx.doi.org/10.1016/j.molmed.2016.02.006 |
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