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Role of TET enzymes in DNA methylation, development, and cancer

The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation. T...

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Detalles Bibliográficos
Autores principales: Rasmussen, Kasper Dindler, Helin, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826392/
https://www.ncbi.nlm.nih.gov/pubmed/27036965
http://dx.doi.org/10.1101/gad.276568.115