Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila

The conserved THO/TREX (transcription/export) complex is critical for pre-mRNA processing and mRNA nuclear export. In metazoa, TREX is loaded on nascent RNA transcribed by RNA polymerase II in a splicing-dependent fashion; however, how TREX functions is poorly understood. Here we show that Thoc5 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Hur, Junho K., Luo, Yicheng, Moon, Sungjin, Ninova, Maria, Marinov, Georgi K., Chung, Yun D., Aravin, Alexei A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826399/
https://www.ncbi.nlm.nih.gov/pubmed/27036967
http://dx.doi.org/10.1101/gad.276030.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826399/
https://www.ncbi.nlm.nih.gov/pubmed/27036967
http://dx.doi.org/10.1101/gad.276030.115

Ejemplares similares