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ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity

AIMS/HYPOTHESIS: Dissipating energy via mitochondrial uncoupling has been suggested to contribute to enhanced insulin sensitivity. We hypothesised that skeletal muscle mitochondria of endurance-trained athletes have increased sensitivity for fatty acid (FA)-induced uncoupling, which is driven by the...

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Detalles Bibliográficos
Autores principales: Sparks, Lauren M., Gemmink, Anne, Phielix, Esther, Bosma, Madeleen, Schaart, Gert, Moonen-Kornips, Esther, Jörgensen, Johanna A., Nascimento, Emmani B. M., Hesselink, Matthijs K. C., Schrauwen, Patrick, Hoeks, Joris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826430/
https://www.ncbi.nlm.nih.gov/pubmed/26886198
http://dx.doi.org/10.1007/s00125-016-3885-8