Cargando…

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans

AIMS/HYPOTHESIS: In contrast to insulin-resistant individuals, insulin-sensitive athletes possess high intramyocellular lipid content (IMCL), good mitochondrial function and high perilipin 5 (PLIN5) levels, suggesting a role for PLIN5 in benign IMCL storage. We hypothesised a role for PLIN5 in modul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gemmink, Anne, Bosma, Madeleen, Kuijpers, Helma J. H., Hoeks, Joris, Schaart, Gert, van Zandvoort, Marc A. M. J., Schrauwen, Patrick, Hesselink, Matthijs K. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826431/ https://www.ncbi.nlm.nih.gov/pubmed/26864436 http://dx.doi.org/10.1007/s00125-016-3865-z

Ejemplares similares

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity
por: Sparks, Lauren M., et al.
Publicado: (2016)

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension
por: Bilet, Lena, et al.
Publicado: (2020)

Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox
por: Daemen, Sabine, et al.
Publicado: (2018)

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria
por: Bosma, Madeleen, et al.
Publicado: (2011)

Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity
por: Gemmink, Anne, et al.
Publicado: (2023)

Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians
por: Gemmink, Anne, et al.
Publicado: (2017)

High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance
por: Phielix, Esther, et al.
Publicado: (2012)

Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity
por: Houzelle, Alexandre, et al.
Publicado: (2020)

Resveratrol‐induced remodelling of myocellular lipid stores: A study in metabolically compromised humans
por: van Polanen, Nynke, et al.
Publicado: (2021)

Exercising your fat (metabolism) into shape: a muscle-centred view
por: Gemmink, Anne, et al.
Publicado: (2020)

Relationship of C5L2 Receptor to Skeletal Muscle Substrate Utilization
por: Roy, Christian, et al.
Publicado: (2013)

A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats
por: van Bree, Bianca W. J., et al.
Publicado: (2016)

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels
por: Bosma, Madeleen, et al.
Publicado: (2012)

Intramyocellular lipid droplets increase with progression of cachexia in cancer patients
por: Stephens, Nathan A., et al.
Publicado: (2011)

Metabolic responses to mild cold acclimation in type 2 diabetes patients
por: Remie, Carlijn M. E., et al.
Publicado: (2021)

PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans
por: de Wit-Verheggen, Vera H. W., et al.
Publicado: (2023)

Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance
por: Hoeks, Joris, et al.
Publicado: (2010)

Exercise training elicits superior metabolic effects when performed in the afternoon compared to morning in metabolically compromised humans
por: Mancilla, Rodrigo, et al.
Publicado: (2020)

Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism
por: op den Kamp, Yvo J.M., et al.
Publicado: (2022)

Lipid droplets and lipotoxicity during autophagy
por: Nguyen, Truc B., et al.
Publicado: (2017)

Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial
por: van Beek, Sten M. M., et al.
Publicado: (2023)

Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation
por: Zhu, Jianxi, et al.
Publicado: (2018)

An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase
por: Zhao, Xuefan, et al.
Publicado: (2022)

Challenges in Pharmacological Intervention in Perilipins (PLINs) to Modulate Lipid Droplet Dynamics in Obesity and Cancer
por: Bombarda-Rocha, Victória, et al.
Publicado: (2023)

Label-free CARS microscopy reveals similar triacylglycerol acyl chain length and saturation in myocellular lipid droplets of athletes and individuals with type 2 diabetes
por: Daemen, Sabine, et al.
Publicado: (2020)

Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups
por: Dahlmans, Dennis, et al.
Publicado: (2017)

Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans
por: Mancilla, Rodrigo F., et al.
Publicado: (2023)

Intramyocellular lipid kinetics and insulin resistance
por: Guo, ZengKui
Publicado: (2007)

Compositional marker in vivo reveals intramyocellular lipid turnover during fasting-induced lipolysis
por: Thankamony, Ajay, et al.
Publicado: (2018)

Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally
por: Du, Jin, et al.
Publicado: (2019)

Skeletal intramyocellular lipid metabolism and insulin resistance
por: Li, Yiran, et al.
Publicado: (2015)

Determinants of intramyocellular lipid accumulation in early childhood
por: Michael, Navin, et al.
Publicado: (2019)

Intramyocellular Triglyceride Content During the Early Course of Type 1 and Type 2 Diabetes
por: Schön, Martin, et al.
Publicado: (2023)

MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans
por: Xie, Kang, et al.
Publicado: (2019)

ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3
por: Zhou, Lijie, et al.
Publicado: (2021)

Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex
por: Li, Yuchuan, et al.
Publicado: (2021)

Intramyocellular Lipid Droplet Size Rather Than Total Lipid Content Is Related to Insulin Sensitivity After 8-Weeks of Overfeeding
por: Covington, Jeffrey D., et al.
Publicado: (2017)

Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients
por: Phielix, Esther, et al.
Publicado: (2008)

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity
por: Meex, Ruth C.R., et al.
Publicado: (2010)

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial
por: Bruls, Yvonne MH, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1j118bsvc3mtok355u8m0r123c