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The inhibition of microRNAs by HIV-1 Tat suppresses beta catenin activity in astrocytes

BACKGROUND: Long term infection with HIV-1, even in the context of therapy, leads to chronic health problems including an array of neurocognitive dysfunctions. The viral Tat protein has previously been implicated in neuropathogenesis through its effect on astrocytes. Tat has also been shown to inhib...

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Detalles Bibliográficos
Autores principales: Sardo, Luca, Vakil, Priyal R., Elbezanti, Weam, El-Sayed, Anas, Klase, Zachary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826512/
https://www.ncbi.nlm.nih.gov/pubmed/27060080
http://dx.doi.org/10.1186/s12977-016-0256-y