Parkinson’s disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

Mitochondrial dysfunction represents a critical step during the pathogenesis of Parkinson disease (PD) and increasing evidence suggests abnormal mitochondrial dynamics and quality control as important underlying mechanisms. The VPS35 gene, encoding a key component of the retromer complex, is the thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Wenzhang, Wang, Xinglong, Fujioka, Hisashi, Hoppel, Charles, Whone, Alan L., Caldwell, Maeve A., Cullen, Peter J., Liu, Jun, Zhu, Xiongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826611/
https://www.ncbi.nlm.nih.gov/pubmed/26618722
http://dx.doi.org/10.1038/nm.3983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826611/
https://www.ncbi.nlm.nih.gov/pubmed/26618722
http://dx.doi.org/10.1038/nm.3983

Ejemplares similares