ΔF508 CFTR interactome remodeling promotes rescue of Cystic Fibrosis

Deletion of phenylalanine 508 of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the major cause of Cystic Fibrosis (CF), one of the most common inherited childhood diseases. The mutated CFTR anion channel is not fully glycosylated and shows minimal activity in bronchial epithelial...

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Detalles Bibliográficos
Autores principales: Pankow, Sandra, Bamberger, Casimir, Calzolari, Diego, Martínez-Bartolomé, Salvador, Lavallée-Adam, Mathieu, Balch, William E., Yates, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826614/
https://www.ncbi.nlm.nih.gov/pubmed/26618866
http://dx.doi.org/10.1038/nature15729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826614/
https://www.ncbi.nlm.nih.gov/pubmed/26618866
http://dx.doi.org/10.1038/nature15729

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