The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease

Expression of the Down syndrome critical region 1 (DSCR1) protein, an inhibitor of the Ca(2+)-dependent phosphatase calcineurin, is elevated in the brains of individuals with Down syndrome (DS) or Alzheimer's disease (AD). Although increased levels of DSCR1 were often observed to be deleterious...

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Detalles Bibliográficos
Autores principales: Lee, Soojin, Bang, Se Min, Hong, Yoon Ki, Lee, Jang Ho, Jeong, Haemin, Park, Seung Hwan, Liu, Quan Feng, Lee, Im-Soon, Cho, Kyoung Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826976/
https://www.ncbi.nlm.nih.gov/pubmed/26659252
http://dx.doi.org/10.1242/dmm.018069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826976/
https://www.ncbi.nlm.nih.gov/pubmed/26659252
http://dx.doi.org/10.1242/dmm.018069

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