Cargando…

Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus

Glucokinase (GCK) is an important enzyme critical for glucose metabolism, and has been targeted as such in the pursuit of a cure for diabetes mellitus. We show that streptozotocin (STZ)-induced diabetic murine model exhibits low GCK expression with high blood glucose levels; moreover, aggravated glo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, G, Teng, X, Zheng, Z, Zhang, R, Peng, L, Zheng, F, Liu, J, Huang, H, Xiong, H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827006/ https://www.ncbi.nlm.nih.gov/pubmed/26752353 http://dx.doi.org/10.1038/gt.2016.1

Ejemplares similares

Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing
por: Wang, Xiaomin, et al.
Publicado: (2021)

Author Correction: Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing
por: Wang, Xiaomin, et al.
Publicado: (2021)

Polymorphism of Glucokinase Gene in Non-Insulin Dependent Diabetes Mellitus
por: Kim, Deog-Yoon, et al.
Publicado: (1994)

Conformational transition pathway of R308K mutant glucokinase in the presence of the glucokinase activator YNKGKA4
por: Yellapu, Nanda Kumar, et al.
Publicado: (2018)

Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus
por: Dzyurkevich, Mikhail S., et al.
Publicado: (2017)

The efficacy and safety of glucokinase activators for the treatment of type-2 diabetes mellitus: A meta-analysis
por: Gao, Qian, et al.
Publicado: (2021)

Heterozygous lys169Glu mutation of glucokinase gene in a Chinese family having glucokinase-maturity-onset diabetes of the young (GCK-MODY)
por: Zhou, W, et al.
Publicado: (2019)

Author Correction: Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus
por: Dzyurkevich, Mikhail S., et al.
Publicado: (2018)

Citrullination of glucokinase is linked to autoimmune diabetes
por: Yang, Mei-Ling, et al.
Publicado: (2022)

Role of Glucokinase in the Subcellular Localization of Glucokinase Regulatory Protein
por: Jin, Ling, et al.
Publicado: (2015)

A glucokinase gene mutation in a young boy with diabetes mellitus, hyperinsulinemia, and insulin resistance
por: Emelyanov, Andrey O, et al.
Publicado: (2017)

Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
por: Cullen, Kirsty S., et al.
Publicado: (2011)

Preliminary screening of mutations in the glucokinase gene of Chinese patients with gestational diabetes
por: Wang, Zhixin, et al.
Publicado: (2017)

The efficacy and safety of glucokinase activators for the treatment of type-2 diabetes mellitus: A protocol for systematic review and meta-analysis
por: Gao, Qian, et al.
Publicado: (2021)

Ebb and Tide of Glucokinase
por: Matschinsky, Franz M.
Publicado: (2001)

Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity
por: Park, Joo-Man, et al.
Publicado: (2015)

Comparative Structural and Functional Analysis of Staphylococcus aureus Glucokinase with other Bacterial Glucokinases
por: Kumar, P. S., et al.
Publicado: (2014)

Decreased expression of hepatic glucokinase in type 2 diabetes
por: Haeusler, Rebecca A., et al.
Publicado: (2014)

Treatment of Diabetes and Long-Term Survival After Insulin and Glucokinase Gene Therapy
por: Callejas, David, et al.
Publicado: (2013)

Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes
por: Lu, Brian, et al.
Publicado: (2018)

Insights into the role of neuronal glucokinase
por: De Backer, Ivan, et al.
Publicado: (2016)

Molecular Physiology of Mammalian Glucokinase
por: Iynedjian, P. B.
Publicado: (2008)

Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes
por: Chow, Elaine, et al.
Publicado: (2023)

Glucokinase activators (GKAs) promise a new pharmacotherapy for diabetics
por: Matschinsky, Franz M, et al.
Publicado: (2010)

Glucokinase Activators for Diabetes Therapy: May 2010 status report
por: Matschinsky, Franz M., et al.
Publicado: (2011)

Diagnosis and management of glucokinase monogenic diabetes in pregnancy: current perspectives
por: Rudland, Victoria L
Publicado: (2019)

Conformational Transition Pathway in the Activation Process of Allosteric Glucokinase
por: Huang, Min, et al.
Publicado: (2013)

Hyperinsulinemic hypoglycemia subtype glucokinase V91L mutant induces necrosis in β-cells via ATP depletion
por: Lu, Brian, et al.
Publicado: (2018)

Glucokinase as an emerging anti-diabetes target and recent progress in the development of its agonists
por: Ren, Yixin, et al.
Publicado: (2022)

Lys169 of Human Glucokinase Is a Determinant for Glucose Phosphorylation: Implication for the Atomic Mechanism of Glucokinase Catalysis
por: Zhang, Jian, et al.
Publicado: (2009)

Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus
por: Wang, Ping, et al.
Publicado: (2017)

Interaction Effect of Genetic Polymorphisms in Glucokinase (GCK) and Glucokinase Regulatory Protein (GCKR) on Metabolic Traits in Healthy Chinese Adults and Adolescents
por: Tam, Claudia H.T., et al.
Publicado: (2009)

Targeting Hepatic Glucokinase in Type 2 Diabetes: Weighing the Benefits and Risks
por: Agius, Loranne
Publicado: (2009)

Pregnancy outcome of Japanese patients with glucokinase–maturity‐onset diabetes of the young
por: Hosokawa, Yuki, et al.
Publicado: (2019)

Cloning and characterization of feline islet glucokinase
por: Lindbloom-Hawley, Sara, et al.
Publicado: (2014)

Thermal Stability of Glucokinases in Thermoanaerobacter tengcongensis
por: Qian, Zhong, et al.
Publicado: (2013)

A new compound heterozygosis for inactivating mutations in the glucokinase gene as cause of permanent neonatal diabetes mellitus (PNDM) in double-first cousins
por: Esquiaveto-Aun, Adriana Mangue, et al.
Publicado: (2015)

Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver
por: Roncero, Isabel, et al.
Publicado: (2013)

Clinical Heterogeneity in Monogenic Diabetes Caused by Mutations in the Glucokinase Gene (GCK-MODY)
por: Cuesta-Muñoz, Antonio L., et al.
Publicado: (2010)

Phenotype Heterogeneity in Glucokinase–Maturity-Onset Diabetes of the Young (GCK-MODY) Patients
por: Wędrychowicz, Anna, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_prr4pckkjomh34h3dnlqs9oke6