Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity

Flagellin has the capacity to activate both Toll-like receptor 5 (TLR5) and Nod-like receptor C4 (NLRC4)/neuronal apoptosis inhibitory protein 5 (NAIP5) inflammasome signaling. We fused E7m (the inactivated E7 of human papillomavirus) to either end of the flagellin protein, and the resulting recombi...

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Detalles Bibliográficos
Autores principales: Lin, Kuo-Hsing, Chang, Li-Sheng, Tian, Chun-Yuan, Yeh, Yi-Chen, Chen, Yu-Jie, Chuang, Tsung-Hsien, Liu, Shih-Jen, Leng, Chih-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827055/
https://www.ncbi.nlm.nih.gov/pubmed/27063435
http://dx.doi.org/10.1038/srep24199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827055/
https://www.ncbi.nlm.nih.gov/pubmed/27063435
http://dx.doi.org/10.1038/srep24199

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