Inhibition of HSV-1 Replication by Gene Editing Strategy

HSV-1 induced illness affects greater than 85% of adults worldwide with no permanent curative therapy. We used RNA-guided CRISPR/Cas9 gene editing to specifically target for deletion of DNA sequences of the HSV-1 genome that span the region directing expression of ICP0, a key viral protein that stim...

Descripción completa

Detalles Bibliográficos
Autores principales: Roehm, Pamela C., Shekarabi, Masoud, Wollebo, Hassen S., Bellizzi, Anna, He, Lifan, Salkind, Julian, Khalili, Kamel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827394/
https://www.ncbi.nlm.nih.gov/pubmed/27064617
http://dx.doi.org/10.1038/srep23146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827394/
https://www.ncbi.nlm.nih.gov/pubmed/27064617
http://dx.doi.org/10.1038/srep23146

Ejemplares similares