TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells

The full-length Nrf1α is processed into distinct isoforms, which together regulate genes essential for maintaining cellular homeostasis and organ integrity, and liver-specific loss of Nrf1 in mice results in spontaneous hepatoma. Herein, we report that the human constitutive Nrf1α, rather than small...

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Detalles Bibliográficos
Autores principales: Ren, Yonggang, Qiu, Lu, Lü, Fenglin, Ru, Xufang, Li, Shaojun, Xiang, Yuancai, Yu, Siwang, Zhang, Yiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827396/
https://www.ncbi.nlm.nih.gov/pubmed/27065079
http://dx.doi.org/10.1038/srep23775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827396/
https://www.ncbi.nlm.nih.gov/pubmed/27065079
http://dx.doi.org/10.1038/srep23775

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