New potential binding determinant for hERG channel inhibitors

Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier K(+) current (I(Kr)) and are essential for the repolarization of the cardiac action potential. hERG1 inhibition by structurally diverse drugs may lead to life threatening arrhythmia. Putative binding determinants...

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Detalles Bibliográficos
Autores principales: Saxena, P., Zangerl-Plessl, E.-M., Linder, T., Windisch, A., Hohaus, A., Timin, E., Hering, S., Stary-Weinzinger, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828713/
https://www.ncbi.nlm.nih.gov/pubmed/27067805
http://dx.doi.org/10.1038/srep24182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828713/
https://www.ncbi.nlm.nih.gov/pubmed/27067805
http://dx.doi.org/10.1038/srep24182

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