The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb

None of the currently used anti-HIV-1 agents can effectively eliminate latent HIV-1 reservoirs, which is a major hurdle to a complete cure for AIDS. We report here that a novel oral BET inhibitor OTX015, a thienotriazolodiazepine compound that has entered phase Ib clinical development for advanced h...

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Detalles Bibliográficos
Autores principales: Lu, Panpan, Qu, Xiying, Shen, Yinzhong, Jiang, Zhengtao, Wang, Pengfei, Zeng, Hanxian, Ji, Haiyan, Deng, Junxiao, Yang, Xinyi, Li, Xian, Lu, Hongzhou, Zhu, Huanzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828723/
https://www.ncbi.nlm.nih.gov/pubmed/27067814
http://dx.doi.org/10.1038/srep24100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828723/
https://www.ncbi.nlm.nih.gov/pubmed/27067814
http://dx.doi.org/10.1038/srep24100

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