CXCR3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-Th17 cytokine milieu and reducing CNS-infiltrating Th17 cells

BACKGROUND: Experimental autoimmune encephalomyelitis (EAE) is a mouse model of multiple sclerosis (MS). It has been shown that Th17 cells are critical for EAE pathogenesis. Mice lacking CXCR3 develop aggravated EAE compared with wild-type (WT) mice. This study investigated the effect of CXCR3 on Th...

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Detalles Bibliográficos
Autores principales: Chung, Chen-Yen, Liao, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828793/
https://www.ncbi.nlm.nih.gov/pubmed/27068264
http://dx.doi.org/10.1186/s12974-016-0536-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828793/
https://www.ncbi.nlm.nih.gov/pubmed/27068264
http://dx.doi.org/10.1186/s12974-016-0536-4

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