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Imipramine protects retinal ganglion cells from oxidative stress through the tyrosine kinase receptor B signaling pathway

Retinal ganglion cell (RGC) degeneration is irreversible in glaucoma and tyrosine kinase receptor B (TrkB)-associated signaling pathways have been implicated in the process. In this study, we attempted to examine whether imipramine, a tricyclic antidepressant, may protect hydrogen peroxide (H(2)O(2)...

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Detalles Bibliográficos
Autores principales: Han, Ming-lei, Liu, Guo-hua, Guo, Jin, Yu, Shu-juan, Huang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829015/
https://www.ncbi.nlm.nih.gov/pubmed/27127489
http://dx.doi.org/10.4103/1673-5374.179066