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Absence of Peroxiredoxin 6 Amplifies the Effect of Oxidant Stress on Mobility and SCSA/CMA3 Defined Chromatin Quality and Impairs Fertilizing Ability of Mouse Spermatozoa

Oxidative stress, the imbalance between reactive oxygen species production and antioxidant defenses, is associated with male infertility. Peroxiredoxins (PRDXs) are antioxidant enzymes with a wide distribution in spermatozoa. PRDX6 is highly abundant and located in all subcellular compartments of th...

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Detalles Bibliográficos
Autores principales: Ozkosem, Burak, Feinstein, Sheldon I., Fisher, Aron B., O'Flaherty, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for the Study of Reproduction, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829091/
https://www.ncbi.nlm.nih.gov/pubmed/26792942
http://dx.doi.org/10.1095/biolreprod.115.137646