Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans

To understand the molecular processes underlying aging, we screened modENCODE ChIP-seq data to identify transcription factors that bind to age-regulated genes in C. elegans. The most significant hit was the GATA transcription factor encoded by elt-2, which is responsible for inducing expression of i...

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Detalles Bibliográficos
Autores principales: Mann, Frederick G., Van Nostrand, Eric L., Friedland, Ari E., Liu, Xiao, Kim, Stuart K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829211/
https://www.ncbi.nlm.nih.gov/pubmed/27070429
http://dx.doi.org/10.1371/journal.pgen.1005956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829211/
https://www.ncbi.nlm.nih.gov/pubmed/27070429
http://dx.doi.org/10.1371/journal.pgen.1005956

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