Quantitative evaluation of first, second, and third generation hairpin systems reveals the limit of mammalian vector-based RNAi

Incorporating miRNA-like features into vector-based hairpin scaffolds has been shown to augment small RNA processing and RNAi efficiency. Therefore, defining an optimal, native hairpin context may obviate a need for hairpin-specific targeting design schemes, which confound the movement of functional...

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Detalles Bibliográficos
Autores principales: Watanabe, Colin, Cuellar, Trinna L., Haley, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Technical Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829305/
https://www.ncbi.nlm.nih.gov/pubmed/26786363
http://dx.doi.org/10.1080/15476286.2015.1128062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829305/
https://www.ncbi.nlm.nih.gov/pubmed/26786363
http://dx.doi.org/10.1080/15476286.2015.1128062

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