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Quantitative evaluation of first, second, and third generation hairpin systems reveals the limit of mammalian vector-based RNAi
Incorporating miRNA-like features into vector-based hairpin scaffolds has been shown to augment small RNA processing and RNAi efficiency. Therefore, defining an optimal, native hairpin context may obviate a need for hairpin-specific targeting design schemes, which confound the movement of functional...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829305/ https://www.ncbi.nlm.nih.gov/pubmed/26786363 http://dx.doi.org/10.1080/15476286.2015.1128062 |