Studies on human eRF3-PABP interaction reveal the influence of eRF3a N-terminal glycin repeat on eRF3-PABP binding affinity and the lower affinity of eRF3a 12-GGC allele involved in cancer susceptibility

The eukaryotic release factor 3 (eRF3) has been involved in the control of mRNA degradation through its association with the cytoplasmic Poly(A) Binding Protein, PABP. In mammals, eRF3 N-terminal domain contains two overlapping PAM2 motifs which specifically recognize the MLLE domain of PABP. In hum...

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Detalles Bibliográficos
Autores principales: Jerbi, Soumaya, Jolles, Béatrice, Bouceba, Tahar, Jean-Jean, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829321/
https://www.ncbi.nlm.nih.gov/pubmed/26818177
http://dx.doi.org/10.1080/15476286.2015.1137421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829321/
https://www.ncbi.nlm.nih.gov/pubmed/26818177
http://dx.doi.org/10.1080/15476286.2015.1137421

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