The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex

The ability to recognize foreign double-stranded (ds)DNA of pathogenic origin in the intracellular environment is an essential defense mechanism of the human innate immune system. However, the molecular mechanisms underlying distinction between foreign DNA and host genomic material inside the nucleu...

Descripción completa

Detalles Bibliográficos
Autores principales: Stratmann, Sarah A, Morrone, Seamus R, van Oijen, Antoine M, Sohn, Jungsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829420/
https://www.ncbi.nlm.nih.gov/pubmed/26673078
http://dx.doi.org/10.7554/eLife.11721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829420/
https://www.ncbi.nlm.nih.gov/pubmed/26673078
http://dx.doi.org/10.7554/eLife.11721

Ejemplares similares