Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain

Morphogen gradients induce sharply defined domains of gene expression in a concentration-dependent manner, yet how cells interpret these signals in the face of spatial and temporal noise remains unclear. Using fluorescence lifetime imaging microscopy (FLIM) and phasor analysis to measure endogenous...

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Detalles Bibliográficos
Autores principales: Sosnik, Julian, Zheng, Likun, Rackauckas, Christopher V, Digman, Michelle, Gratton, Enrico, Nie, Qing, Schilling, Thomas F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829421/
https://www.ncbi.nlm.nih.gov/pubmed/27067377
http://dx.doi.org/10.7554/eLife.14034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829421/
https://www.ncbi.nlm.nih.gov/pubmed/27067377
http://dx.doi.org/10.7554/eLife.14034

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