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Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain
Morphogen gradients induce sharply defined domains of gene expression in a concentration-dependent manner, yet how cells interpret these signals in the face of spatial and temporal noise remains unclear. Using fluorescence lifetime imaging microscopy (FLIM) and phasor analysis to measure endogenous...
Autores principales: | Sosnik, Julian, Zheng, Likun, Rackauckas, Christopher V, Digman, Michelle, Gratton, Enrico, Nie, Qing, Schilling, Thomas F |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829421/ https://www.ncbi.nlm.nih.gov/pubmed/27067377 http://dx.doi.org/10.7554/eLife.14034 |
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