T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

Crucial roles for T-box3 in development are evident by severe limb malformations and other birth defects caused by T-box3 mutations in humans. Mechanisms whereby T-box3 regulates limb development are poorly understood. We discovered requirements for T-box at multiple stages of mouse limb development...

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Detalles Bibliográficos
Autores principales: Emechebe, Uchenna, Kumar P, Pavan, Rozenberg, Julian M, Moore, Bryn, Firment, Ashley, Mirshahi, Tooraj, Moon, Anne M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829432/
https://www.ncbi.nlm.nih.gov/pubmed/27046536
http://dx.doi.org/10.7554/eLife.07897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829432/
https://www.ncbi.nlm.nih.gov/pubmed/27046536
http://dx.doi.org/10.7554/eLife.07897

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