Modeling the Initiation of Ewing Sarcoma Tumorigenesis in Differentiating Human Embryonic Stem Cells

Oncogenic transformation in Ewing sarcoma tumors is driven by the fusion oncogene EWS-FLI1. However, despite the well-established role of EWS-FLI1 in tumor initiation, the development of models of Ewing sarcoma in human cells with defined genetic elements has been challenging. Here, we report a nove...

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Detalles Bibliográficos
Autores principales: Gordon, David J., Motwani, Mona, Pellman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829493/
https://www.ncbi.nlm.nih.gov/pubmed/26455317
http://dx.doi.org/10.1038/onc.2015.368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829493/
https://www.ncbi.nlm.nih.gov/pubmed/26455317
http://dx.doi.org/10.1038/onc.2015.368

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