Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABA(A) receptor subtype

Agonists at the benzodiazepine-binding site of GABA(A) receptors (BDZs) enhance synaptic inhibition through four subtypes (α1, α2, α3 and α5) of GABA(A) receptors (GABA(A)R). When applied to the spinal cord, they alleviate pathological pain; however, insufficient efficacy after systemic administrati...

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Detalles Bibliográficos
Autores principales: Ralvenius, William T., Benke, Dietmar, Acuña, Mario A., Rudolph, Uwe, Zeilhofer, Hanns Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829939/
https://www.ncbi.nlm.nih.gov/pubmed/25865415
http://dx.doi.org/10.1038/ncomms7803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829939/
https://www.ncbi.nlm.nih.gov/pubmed/25865415
http://dx.doi.org/10.1038/ncomms7803

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