Autophagy downregulation contributes to insulin resistance mediated injury in insulin receptor knockout podocytes in vitro

It is unknown whether autophagy activity is altered in insulin resistant podocytes and whether autophagy could be a therapeutic target for diabetic nephropathy (DN). Here we used shRNA transfection to knockdown the insulin receptor (IR) gene in cultured human immortalized podocytes as an in vitro in...

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Detalles Bibliográficos
Autores principales: Xu, Ying, Zhou, Qi, Xin, Wei, Li, Zhaoping, Chen, Liyong, Wan, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830256/
https://www.ncbi.nlm.nih.gov/pubmed/27077005
http://dx.doi.org/10.7717/peerj.1888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830256/
https://www.ncbi.nlm.nih.gov/pubmed/27077005
http://dx.doi.org/10.7717/peerj.1888

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