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Autophagy downregulation contributes to insulin resistance mediated injury in insulin receptor knockout podocytes in vitro
It is unknown whether autophagy activity is altered in insulin resistant podocytes and whether autophagy could be a therapeutic target for diabetic nephropathy (DN). Here we used shRNA transfection to knockdown the insulin receptor (IR) gene in cultured human immortalized podocytes as an in vitro in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
PeerJ Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830256/ https://www.ncbi.nlm.nih.gov/pubmed/27077005 http://dx.doi.org/10.7717/peerj.1888 |