Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

Mutations in the human telomerase RNA (hTR), the telomerase RNP component dyskerin (DKC1), and the poly(A) ribonuclease (PARN) can lead to reduced levels of hTR and dyskeratosis congenita (DC). However, the enzymes and mechanisms responsible for hTR degradation are unknown. We demonstrate that defec...

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Detalles Bibliográficos
Autores principales: Shukla, Siddharth, Schmidt, Jens C., Goldfarb, Katherine C., Cech, Thomas R., Parker, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830462/
https://www.ncbi.nlm.nih.gov/pubmed/26950371
http://dx.doi.org/10.1038/nsmb.3184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830462/
https://www.ncbi.nlm.nih.gov/pubmed/26950371
http://dx.doi.org/10.1038/nsmb.3184

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